Indo-American Journal of Life Sciences and Biotechnology
type: channel
description: Editor- In-Chief: Dr. Mai S. Mabrouk Title proper: Indo-American Journal of Life Sciences and Biotechnology Subject: Life Sciences Publisher: Unicorn Publishers ISSN : 2347-2243 Dates of publication: 2012 Frequency: Quarterly Language: English Country: India Medium: Online Indexed by: CROSSREF Indexed by: ROAD Indexed by: THE KEEPERS Title DOI of the Journal: http://doi.org/10.62644/issn.2347-2243
publisher: Unicorn Publications
language: en
publication name: Indo-American Journal of Life Sciences and Biotechnology
issn: 2347-2243
items: AI-Based Protein Structure Prediction in Drug Target Identification
items: Synthetic Biology for Sustainable Bioproduction Systems
items: Single-Cell Omics Approaches in Disease Mechanism Discovery
items: CRISPR-Cas Systems in Functional Genomics and Therapeutics
items: Materials for Pharmaceutical Dosage Forms: Aspects of Controlled Release Drug Delivery and Molecular Pharmaceutics
items: A study of the benefits and mechanisms of naturally occurring small molecule chemicals in the prevention and treatment of colorectal cancer
items: Leading Trends in Pharmaceutical Research: Top Cited Articles in Molecular Pharmaceutics
items: Therapeutic Potential of Targeting IncRNA-Mediated Epigenetic Modification's in Liver Fibrosis
items: Longitudinal Analysis of Social Support and Emotional Control Among Engineering Students in Vietnam”
items: Design Plan for a Two-Group Randomized Trial of THR Products in Economically Developing Areas
items: Siddha-Based Comparative Analysis of Water Quality Using Terminalia chebula and Terminalia bellerica
items: Chewable Tablets Made From Momordica Charantia [Bitter Melon] A Hypothesis Driven Strategy For Managing Diabetes Mellitus
items: Phytogenic Nanoparticle Engineering: Emerging Trends in Sustainable Biosynthesis and Functional Applications
items: Exosomal Delivery of Bipactive Compounds from Ancient Chinese Botanicals in the Management of Neurological Disorders
items: Neuropharmacological Profiling of Acanthus ilicifolius: A Coastal Mangrove's Potential in CNS Depression and Analgesia"
items: Macrophage-Based Therapeutic Strategies: Phenotypic Transition Control and Drug Delivery System Development
items: Effects of Phosphate Fertilizers on Soybean Performance
items: Economic Evaluation of FDA-Approved Small Molecule Protein Kinase Inhibitors in Oncology and Non-Oncology Indications in the United States
items: Homeopathy's effects on HIV-positive individuals
items: A review of the phytochemical studies of Momordica charantia
items: A STUDY TO ASSESS THE EFFECTIVENESS OF PLANNED TEACHING PROGRAMME REGARDING CHILDHOOD OBESITY AMONG THE MOTHERS OF SCHOOL GOING CHILDREN IN URBAN AREA
items: Stress tolerance and adaptation as criteria for evaluating top rice genotypes in both typical and water-limited settings
items: Animal items containing heavy metals, such as milk and red meat
items: Rice crop enhancement using the CRISPR/Cas9 genome editing technology
items: The ultrastructure, control, and function of plasmodesmata in the transport of assimilates across plant cells
items: SCREENING OF ALLELOPATHIC ACTIVITY OF CARDIOSPERMUM HALICACABUMLINN. (KAPALPHODI) ON TRITICUM AESTIVUM (WHEAT) AND VIGNA RADIATA (MUG)
items: A case report on the 50th millesimal potency of homeopathic treatment for chronic cholelithiasis
items: To determine the efficacy of homoeopathic remedies for chronic rhinosinusitis, researchers conducted a randomized, placebo-controlled, parallel-arm experiment
items: A report on a case of prurigo nodularis that responded to homeopathy
items: A web-based cross-sectional research on the knowledge, awareness, attitude, and behavior of Indian homoeopathic physicians about pharmacovigilance in homoeopathy

AI-Based Protein Structure Prediction in Drug Target Identification
type: item
description: The deployment of AlphaFold2 and its successors--including ESMFold, RoseTTAFold, and AlphaFold3--has resolved the protein structure prediction problem for the majority of the human proteome, generating a structural database of over 214 million protein models covering virtually all catalogued proteins across 48 organisms. This transformative capability has fundamentally accelerated the drug target identification pipeline by enabling structure-based druggability assessment, cryptic binding site discovery, and protein-protein interaction interface characterisation at proteome scale--without the time and cost constraints of experimental structure determination. This study applies an integrated AI-driven pipeline combining AlphaFold2 structural models, FoldSeek structural similarity search, DiffDock-L deep learning molecular docking, and PLINDER protein-ligand interaction scoring to systematically assess druggability and identify novel binding sites across 847 previously unstructured proteins in three high-priority disease proteomes: type 2 diabetes (T2D, 312 targets), Alzheimer's disease (AD, 287 targets), and colorectal cancer (CRC, 248 targets). Of 847 targets assessed, 312 (36.8%) were classified as druggable (DScore >= 0.6) using structure-predicted models compared to only 187 (22.1%) classified as druggable from sequence-based predictions alone--a 66.8% expansion of the druggable target space. Cryptic binding site analysis using CryptoSite and MDPocket identified 1,247 previously uncharacterised pockets, of which 89 showed druggability scores exceeding known drug targets in the same disease class. Molecular docking of the ChEMBL35 approved drug library (9,847 compounds) against newly identified binding sites identified 34 high-confidence drug repurposing opportunities (DiffDock confidence score > 0.7, PLINDER similarity to known drug-target complexes > 0.6), including metformin against an AD-associated AMPK regulatory subunit conformation not previously characteris…
subject: Articles
  topic: section
subject: phaFold2
  topic: keywords
subject: Al
  topic: keywords
subject: Protein structure prediction
  topic: keywords
subject: Drug target identification
  topic: keywords
subject: Druggability
  topic: keywords
subject: Cryptic binding seits
  topic: keywords
creator: Anna Klein
creator: Helena Ivanov
creator: Hugo Hansen
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-01-01
publication date: 2026-01-01
starting page: 28
ending page: 36
doi: 10.62644/v23.i01.2026.pp28-36

Synthetic Biology for Sustainable Bioproduction Systems
type: item
description: Synthetic biology--the application of engineering principles including standardisation, modularity, and design-build-test-learn cycles to the construction of novel biological systems--offers transformative potential for sustainable bioproduction of chemicals, fuels, materials, and therapeutics that currently depend on fossil-derived feedstocks and resource-intensive chemical synthesis routes. This study designs, constructs, and optimises three synthetic metabolic pathways in Escherichia coli BL21(DE3) and Saccharomyces cerevisiae BY4741 for the biosynthesis of three high-value industrial compounds: lycopene (terpenoid antioxidant, EUR 800/kg), muconic acid (nylon precursor, EUR 2,400/kg), and PHB (polyhydroxybutyrate, biodegradable polymer, EUR 4,000/kg). Using a Design-Build-Test-Learn (DBTL) framework integrating metabolic modelling (COBRA v3.0), combinatorial promoter/RBS optimisation (Anderson promoter library, 5'-UTR calculator), flux balance analysis (FBA)-guided gene knockout selection, and adaptive laboratory evolution (ALE, 30 serial passages), final engineered strains achieved titres of 847 mg/L lycopene (E. coli, 14.2-fold improvement over wild-type MEP pathway baseline), 18.4 g/L muconic acid (E. coli, 92% of theoretical maximum yield), and 62.4% PHB cell dry weight (E. coli, 98.1% substrate conversion efficiency). Multi-omics characterisation of evolved strains (transcriptomics, metabolomics, proteomics) revealed the molecular basis of performance gains and identified seven novel regulatory targets for future strain improvement. Techno-economic analysis confirmed positive net present value (NPV = EUR 28.4M at 10-year horizon) for lycopene and muconic acid bioproduction at demonstration scale (100 m3 fermenter), providing a blueprint for industrial synthetic biology scale-up.
subject: Articles
  topic: section
subject: Synthetic biology
  topic: keywords
subject: Metabolic engineering
  topic: keywords
subject: DBTL cycle
  topic: keywords
subject: Lycopene; Muconic acid
  topic: keywords
creator: Erik Klein
creator: Nina Nowak
creator: Lea Lindberg
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-01-01
publication date: 2026-01-01
starting page: 19
ending page: 27
doi: 10.62644/v23.i01.2026.pp19-27

Single-Cell Omics Approaches in Disease Mechanism Discovery
type: item
description: Single-cell omics technologies--encompassing single-cell RNA sequencing (scRNA-seq), single-cell ATAC-seq (scATAC-seq), single-cell proteomics, spatial transcriptomics, and multi-modal CITE-seq--have fundamentally transformed the resolution at which cellular heterogeneity, developmental trajectories, and disease mechanisms can be characterised, enabling the dissection of complex tissues into their constituent cell types and states at unprecedented granularity. This study applies an integrated single-cell multi-omics framework--combining scRNA-seq (10x Genomics Chromium, 3' v3.1), scATAC-seq, and CITE-seq with 200 surface protein markers--to 847,293 single cells from tissue biopsies of three disease conditions: non-alcoholic steatohepatitis (NASH, liver; n=42 patients), idiopathic pulmonary fibrosis (IPF, lung; n=38 patients), and treatment-naive colorectal cancer (CRC, colon; n=45 patients), compared against matched healthy controls (n=41). Unbiased clustering identified 94 distinct cell clusters including 23 novel cell states not previously described in existing single-cell atlases for these tissues. Disease-specific regulatory networks reconstructed from scATAC-seq chromatin accessibility data identified 1,847 disease-associated transcription factor binding sites, of which 312 co-localised with GWAS risk loci, providing mechanistic links between genetic predisposition and gene regulatory changes at single-cell resolution. Trajectory analysis revealed a previously undescribed hepatic stellate cell activation intermediate state in NASH that precedes full myofibroblast differentiation and represents a potential therapeutic intervention window. Ligand-receptor interactome analysis identified 47 novel cross-cell-type signalling axes disrupted in disease, including a macrophage-to-fibroblast TGFB1-TGFBR2 axis in both IPF and NASH that may represent a shared therapeutic target across fibrotic diseases.
subject: Articles
  topic: section
subject: Single-cell RNA-seq
  topic: keywords
subject: scATAC-seq
  topic: keywords
subject: CITE-seq
  topic: keywords
subject: Spatial transcriptomics
  topic: keywords
creator: Matteo Muller
creator: Isabella Silva
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-01-01
publication date: 2026-01-01
starting page: 10
ending page: 18
doi: 10.62644/v23.i01.2026.pp10-18

CRISPR-Cas Systems in Functional Genomics and Therapeutics
type: item
description: CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins) systems have revolutionised functional genomics and therapeutic development by providing programmable, precise, and efficient tools for genome editing, transcriptional regulation, epigenome remodelling, and base editing across virtually all organism types. This review comprehensively surveys the mechanistic diversity of CRISPR-Cas systems--from the nuclease-active SpCas9 and SaCas9 to the RNA-targeting CasRx, the single-base editors BE3 and ABE, and the versatile prime editors PE2 and PE3--and evaluates their application across two transformative domains: functional genomics, including genome-wide CRISPR screens, CRISPRi/CRISPRa transcriptional perturbation libraries, and epigenome editing for gene regulatory network dissection; and therapeutics, covering ex-vivo haematopoietic stem cell editing for sickle cell disease and beta-thalassaemia, in-vivo liver-targeted delivery for transthyretin amyloidosis (NTLA-2001), CAR-T cell engineering, and emerging in-vivo CNS and muscle delivery approaches. Clinical trial progress as of 2025 is reviewed, including the landmark FDA and EMA approval of Casgevy (exa-cel) for sickle cell disease and beta-thalassaemia in December 2023--the first approved CRISPR therapeutic--and the expanding pipeline of 47 active clinical trials. Delivery systems, off-target safety profiles, immunogenicity, and regulatory considerations are critically evaluated. The review concludes by identifying the five most impactful near-term advances: prime editing clinical translation, in-vivo muscle CRISPR delivery, epigenome-only editing, pan-genome CRISPR libraries, and AI-guided guide RNA design.
subject: Articles
  topic: section
subject: CRISPR-Cas9
  topic: keywords
subject: Genome editing
  topic: keywords
subject: Functional genomics
  topic: keywords
subject: CRISPR screens
  topic: keywords
subject: Base editing
  topic: keywords
creator: Jonas Ivanov
rights: Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2026-01-01
publication date: 2026-01-01
starting page: 01
ending page: 09
doi: 10.62644/v23.i01.2026.pp1-9

Materials for Pharmaceutical Dosage Forms: Aspects of Controlled Release Drug Delivery and Molecular Pharmaceutics
type: item
description: Compared to immediate release distribution, controlled release delivery has several benefits (such as microparticles and nanoparticles) and is accessible for a variety of administration methods. These benefits include less frequent dosing, improved therapeutic control, and fewer adverse effects; as a result, patients are more receptive to these dose forms. Numerous commercialized controlled release products have been made possible by advancements in polymer material science, particle engineering design, manufacturing, and nanotechnology. Several more are now in pre-clinical and clinical research.
subject: Articles
  topic: section
subject: pharmaceutical dosage forms
  topic: keywords
subject: copolymers, biomaterials
  topic: keywords
subject: biodegradable
  topic: keywords
creator: M.Kishore Babu
creator: K.Ashok
creator: Ch.Ajay Babu
creator: M. Indira
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-08-02
publication date: 2025-08-02
starting page: 1
ending page: 26

A study of the benefits and mechanisms of naturally occurring small molecule chemicals in the prevention and treatment of colorectal cancer
type: item
description: Colorectal cancer (CRC) was the third most common disease worldwide in 2022 and the leading cause of cancer deaths that year, and it is projected to significantly increase that number by 2040. Diet, lifestyle, and genetic factors all have a role in the cancerous development of normally functioning colonic cells, which takes a long time (usually more than ten years) and is accompanied by complicated interactions among several cellular pathways. The fact that there are significant variations in CRC incidence and death rates between demographic groupings, geographical locations, and biological sexes further supports the idea that CRC is present. Thus, a great method to lessen the burden of CRC in the next decades might be to intervene or halt the progression of the disease in high-risk groups as soon as possible. Some of the many benefits of NDSMCs—small molecule compounds generated from natural sources—include structural diversity, distinct biological activity, little toxicity, and the ability to target many targets at once. New data reveals that NDSMCs have the ability to treat colorectal cancer (CRC) by regulating apoptosis and autophagy, as well as by influencing the gut microbiota and inducing ferroptosis. Nevertheless, there is a dearth of thorough evaluations in this domain. Therefore, this study aims to give significant insights for treatment methods, preventative measures, and innovative medication development by comprehensively summarizing the research accomplishments over the last 5 years regarding the mechanisms of NDSMCs in battling CRC. We also go over the limits and clinical development of certain NDSMCs in treating CRC.
subject: Articles
  topic: section
subject: colorectal cancer
  topic: keywords
subject: natural derived small molecule compounds
  topic: keywords
subject: mechanism of action
  topic: keywords
creator: M. Kishore Babu
creator: K. Balaram Kumar
creator: L. Ramachandra Reddy
creator: B. Sasidhar
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-05-02
publication date: 2025-05-02
starting page: 37
ending page: 56

Leading Trends in Pharmaceutical Research: Top Cited Articles in Molecular Pharmaceutics
type: item
description: Several Molecular Pharmaceutics publications that garnered a lot of citations in 2023 are highlighted in this collection. These widely referenced publications provide insightful information about the study areas that readers are presently most interested in. They showcase ground-breaking findings in addition to pertinent analyses and viewpoints on important topics of the day.
subject: Articles
  topic: section
subject: pandemic
  topic: keywords
subject: adjuvants
  topic: keywords
subject: proteins
  topic: keywords
creator: M. Kishore Babu
creator: M. Vamshi Krishna
creator: N. Jansi Rani
creator: P. Chandra Sekhar
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-02-03
publication date: 2025-02-03
starting page: 109
ending page: 112

Therapeutic Potential of Targeting IncRNA-Mediated Epigenetic Modification's in Liver Fibrosis
type: item
description: Excessive growth of connective tissue in an organ that is prone to cirrhosis is the hallmark of the dangerous condition known as liver fibrosis. New approaches to the diagnosis and therapy of liver fibrosis can only be developed by first understanding the processes that cause this illness to progress. There is mounting evidence that a subset of RNAs known as long non-coding RNAs (lncRNAs) contribute significantly to the development of liver fibrosis and might represent promising new treatment targets. This article provides a comprehensive overview of long non-coding RNAs (lncRNAs) in liver fibrosis, including their function, pathogenetic pathways, relevant investigations, and potential diagnostic markers and therapeutic targets. Potentially ground-breaking methods for detecting and treating liver fibrosis may emerge from the discovery and investigation of these lncRNAs. To identify lncRNAs as possible biomarkers and treatment targets and to comprehend the molecular pathways linked to liver fibrosis, more study is required.
subject: Articles
  topic: section
subject: Liver fibrosis
  topic: keywords
subject: Long non-coding RNAs
  topic: keywords
subject: lncRNAs
  topic: keywords
creator: M Kishore Babu
creator: N. DanamurthyT
creator: Sujatha
creator: M.Jalaiah
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-03-03
publication date: 2025-03-03
starting page: 102
ending page: 108

Longitudinal Analysis of Social Support and Emotional Control Among Engineering Students in Vietnam”
type: item
description: Within the setting of Vietnam National University Ho Chi Minh City, this research explores the complex link between students' perceptions of social support and their involvement in emotion regulation. This study uses a quantitative technique to reveal complex patterns and relationships by drawing data from 675 individuals in a thorough survey. The results show that there is a complex pattern to how students regulate their emotions; students who identify as male show more involvement and mostly use techniques that focus on self-support and emotional awareness. Importantly, individuals' reported levels of social support were moderate on the whole, with friends being the most common source. The effect of educational settings is highlighted by differences in the level of involvement in emotion regulation, especially among engineering students. Students' emotional coping mechanisms are shaped by their families and significant others, as the research shows that there is a positive association between perceived social support and the frequency of participating in behavior control measures. In light of these findings, it is clear that educational environments need individualized treatments to help students develop stronger social support networks and better control their emotions. Finally, this study highlights the need for strategies that strengthen social support systems and emotion management skills in educational settings, and it contributes to students' holistic development by emphasizing the significance of fostering an environment that supports students' emotional well-being alongside their academic pursuits
subject: Articles
  topic: section
subject: Emotional management
  topic: keywords
subject: Social support
  topic: keywords
subject: University students
  topic: keywords
creator: M Kishore Babu
creator: P Krupa Rani
creator: M Bhargavi
creator: T Pavani
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-03-03
publication date: 2025-03-03
starting page: 93
ending page: 101

Design Plan for a Two-Group Randomized Trial of THR Products in Economically Developing Areas
type: item
description: As a result of increasing tobacco smoking, LMICs may account for a disproportionately high number of deaths caused by tobacco use worldwide. In order to deploy tobacco harm reduction (THR) products as an effective smoking cessation approach to limit escalating tobacco use in LMICs, it is vital to understand and perform RCTs in this setting. In this randomized controlled trial (RCT), 258 adult smokers will participate over the course of 52 weeks; each arm will get a 12-week treatment and a 12-week follow-up period. After participants fulfill the requirements and provide their informed permission, they will be randomly assigned to one of two treatment groups: (1) e-cigarettes with individual counseling and a nicotine patch dose of 21 mg or (2) nicotine patches with individual counseling and a nicotine concentration of 18 mg/ml. Both a screening and a baseline (BL) visit will be planned for participants at the trial location. A total of eight study visits, comprising five treatment sessions and three follow-up visits, will be arranged for the participants. These visits will include both in-person contacts at the trial site and telephone follow-up. In all, eight visits are scheduled for weeks 1, 2, 4, 8, 12, 18, 24, and 52. For the purpose of quantifying biochemically confirmed smoking abstinence, the trial site will use exhaled carbon monoxide evaluation.
subject: Articles
  topic: section
subject: Smoking cessation
  topic: keywords
subject: Tobacco harm reduction
  topic: keywords
subject: E-cigarettes
  topic: keywords
creator: M Kishore Babu
creator: M Bhargavi
creator: T Pavani
creator: D Divyasri
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-01-02
publication date: 2025-01-02
starting page: 85
ending page: 92

Siddha-Based Comparative Analysis of Water Quality Using Terminalia chebula and Terminalia bellerica
type: item
description: The purpose of this descriptive observational research was to assess the clinic epidemiological profile and seroprevalence of chronic hepatitis (HBV) and hepatitis C (HCV) in patients at Government Medical College and Memorial Government Hospital in Haldwani, Uttarakhand. and 141 HCV-positive patients (1.97%) during a two-year period. 141 HCV-positive cases (1.97%) and thorough data were used to evaluate the patients. Laboratory testing, imaging investigations, and thorough clinical assessments were used to evaluate the patients; SPSS was used to analyze the data. While HBV patients had substantially higher serum bilirubin (p=0.005) and SGOT levels (p=0.0057), most HCV patients had advanced liver disease, as shown by higher rates of ascites (13.97%), jaundice (11.73%), and increased urea levels (p=0.03). Age, gender, and education did not significantly vary across groups, according to sociodemographic analysis; however, geographic patterns indicated that HBV was more common in Nainital (63.2%) and HCV was more common in Udham Singh Nagar (27.7%) and Bijnor (29.1%). These results highlight the critical need for focused interventions to lower the incidence of viral hepatitis in marginalized communities, such as awareness campaigns, preventative measures, and region-specific healthcare initiatives.
subject: Articles
  topic: section
subject: observational
  topic: keywords
subject: epidemiological
  topic: keywords
subject: campaigns
  topic: keywords
creator: Smt.S.Gowthami
creator: Ms T Pavani
creator: Mrs D Divyasri
creator: Mr T Malyadri
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-02-03
publication date: 2024-02-03
starting page: 41
ending page: 49

Chewable Tablets Made From Momordica Charantia [Bitter Melon] A Hypothesis Driven Strategy For Managing Diabetes Mellitus
type: item
description: Diabetes Mellitus, the metabolic disorder that causes persistently high blood sugar levels, is a major public health concern across the world. More than 61 million people in India deal with diabetes, earning the country the nickname "Capital of Diabetes." complications caused by diabetes. Phytochemicals and essential medications are abundant in plants, making them an excellent natural resource. The bitter melon, or Momordica charantia (MC), is a useful remedy for diabetes mellitus due to its high phytochemical content. One name for Momordica charantia is "vegetable insulin" due to the hypoglycemic effects caused by its alkaloids and peptides, which are similar to insulin and Charantin. Much has been said and written about bitter melon's action mechanism. Because of their slow disintegration or dissolving in the mouth, the active ingredient in medicated Momordica charantia lozenges is released gradually. This is due to the fact that the lozenges dosage form has a good oral retention time in, increases bioavailability, and decreases gastrointestinal irritation. Both topical and systemic administration are possible with this dose type. The development of chewable lozenges containing Momordica charantia as a medication for type 2 diabetes is central to our working hypothesis. The article touches on a few bits of data from bitter melon investigations, both in the pre-clinical and clinical stages. Multiple investigations in the fields of physiology, pharmacology, and biochemistry have provided credence to our theory. The paper also details the process that was utilized to create the chewable lozenges. Additionally, the essay has covered many bitter melon and herbal lozenge formulations that are available for purchase.
subject: Articles
  topic: section
subject: Diabetes Mellitus
  topic: keywords
subject: Momordica
  topic: keywords
subject: Chewable lozenges
  topic: keywords
creator: M Kishore Babu
creator: Ch. Vineela
creator: S Keerthana Madhuri
creator: Ch. Devadasu
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-01-02
publication date: 2025-01-02
starting page: 62
ending page: 84

Phytogenic Nanoparticle Engineering: Emerging Trends in Sustainable Biosynthesis and Functional Applications
type: item
description: Recent years have seen tremendous progress in the area of bio-nanotechnology, especially in the production and use of bio-nanoparticles (BNPs). The green synthesis of BNPs utilizing biological organisms including algae, fungus, bacteria, and plants is the main topic of this paper. Using these organisms to synthesize nanoparticles provides a sustainable and environmentally benign substitute for traditional chemical and physical processes, which often need hazardous chemicals and a lot of energy. The synthesis of nanoparticles with a variety of shapes and sizes is facilitated by phytochemicals found in plant extracts, distinct metabolic pathways, biomolecules in bacteria and fungus, and the complex biochemical makeup of algae. The broad range of uses of BNPs in industries such as wastewater treatment, fuel cells, energy production, and medicines is further examined in this paper. BNPs have shown effectiveness in antibacterial, anti-inflammatory, antioxidant, and anticancer properties in treatments. In order to increase sustainability and efficiency, BNPs are being incorporated into fuel cells and other energy generating systems, such as bio-diesel, in the energy industry. These devices' performance is improved by their high surface area and catalytic qualities. BNPs are used in wastewater treatment, another crucial sector, to remove organic pollutants, microbiological contaminants, and heavy metals, providing an economical and sustainable approach to water purification. The potential of bio-nanoparticles produced using environmentally friendly techniques is highlighted in this thorough analysis. It draws attention to the need of further study in order to improve synthesis procedures, comprehend mechanisms of action, and broaden the range of applications. By addressing the benefits and some of the most urgent issues in energy, environmental sustainability, and medical, BNPs may open the door for creative and long-lasting technological breakthroughs in the future.
subject: Articles
  topic: section
subject: bio-nanoparticles
  topic: keywords
subject: green synthesis
  topic: keywords
subject: therapeutic properties
  topic: keywords
creator: M Kishore Babu
creator: S.Deepthi
creator: G.Raveendra Babu
creator: G. Manasa
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-01-01
publication date: 2025-01-01
starting page: 48
ending page: 61

Exosomal Delivery of Bipactive Compounds from Ancient Chinese Botanicals in the Management of Neurological Disorders
type: item
description: A bioactive substance derived from Chinese herbal remedies with known biological activity and pharmacological effects is known as a traditional Chinese medicine (TCM) monomer. It has drawn a lot of interest for the treatment of neurological disorders. However, TCM monomers' weak solubility and poor blood-brain barrier (BBB) crossing capabilities restrict their use. With special benefits including low toxicity, low immunogenicity, high blood stability, and the capacity to pass the blood-brain barrier, exosomes—small extracellular vesicles (EVs)) with a diameter of 30 to 150 nm—can be used as drug delivery vehicles that directly target cells or tissues. In addition to comparing exosomes with other comparable drug delivery methods, this study covers the biogenesis, components, stability, surface modification, separation technique, benefits, and drawbacks of exosomes as drug carriers. Exosome-encapsulated TCM monomers also have neuroprotective effects, such as anti-oxidation, anti-apoptosis, anti-inflammation, and anti-mitophagy, in a variety of neuronal diseases, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, and cerebral ischemia and reperfusion (CI/R) injury. They also have anti-drug resistance, anti-tumorigenesis, and anti-angiogenesis properties, as well as promoting the development of an exosome-based delivery tool in targeted therapy for neuronal diseases.
subject: Articles
  topic: section
subject: promoting
  topic: keywords
subject: Parkinson's disease
  topic: keywords
subject: pharmacological
  topic: keywords
creator: G Buela Priyanka
creator: Md.Yunoos
creator: S V Subba Rao
creator: G. Manasa
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2023-11-02
publication date: 2023-11-02
starting page: 19
ending page: 51

Neuropharmacological Profiling of Acanthus ilicifolius: A Coastal Mangrove's Potential in CNS Depression and Analgesia"
type: item
description: An exceptionally abundant supply of significant chemicals with structurally unique and physiologically active metabolites may be found in the marine environment. Mangrove plants have long been utilized in traditional medicine to cure a variety of illnesses all around the globe. Very few efforts have been undertaken to test the validity of these claims in controlled trials, despite the fact that several mangroves and mangal companions are suggested in traditional medicine as being effective against a variety of ailments. Acanthus ilicifolius Linn, often known as sea holly (acanthaceae), is a salty plant that is typically found around the southeast coastlines of India. It is well-known for its wide range of secondary metabolites and its traditional uses. Using a Soxhlet apparatus, the leaves of Acanthus ilicifolius were gathered, shade-dried, ground into a coarse powder, defatted with petroleum ether, and then extracted with ethanol. Assessment of the effects of an ethanolic extract of Acanthus ilicifolius leaves as a central nervous system depressant. Mice were subjected to a number of behavioral tests, including the Tail Suspension Test (TST) and the Forced Swimming Test (FST). The immobility periods in the FST extract at dosages of 100, 250, and 500 mg/kg were considerably (P<0.0001) longer than those in the control group. When compared to a normal medication, TST considerably lengthens the immobility period when the dosage is increased. The drug's interaction with the GABA ergic system may be the cause of these depressed patterns.
subject: Articles
  topic: section
subject: exceptionally
  topic: keywords
subject: Acanthus
  topic: keywords
subject: interaction
  topic: keywords
creator: B.Revathi
creator: N. Danamurthy
creator: T. Sujatha
creator: M.Jalaiah
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-02
publication date: 2024-01-02
starting page: 34
ending page: 40

Macrophage-Based Therapeutic Strategies: Phenotypic Transition Control and Drug Delivery System Development
type: item
description: Macrophages, being highly phenotypic changeable immune cells, have distinct functions in different clinical situations. Modifying and managing macrophage morphologies is seen as a unique possible therapeutic intervention. In the meanwhile, several transmembrane proteins that attach on the macrophage membrane's surface remain comparatively preserved, maintaining its functional characteristics including tumor targeting and inflammatory chemotaxis. As a result, a number of medication delivery mechanisms associated with certain macrophage membrane proteins are often used to treat chronic inflammatory disorders. The regulation of macrophage phenotypes and their polarization processes, the design and implementation of site-specific targeted drug delivery systems in vivo based on macrophages and their derived membrane receptors, and a summary of macrophage-based strategies for chronic diseases are all covered in this review. It seeks to advance knowledge of macrophages' role in immunoregulation and suggests tailored therapy strategies based on macrophages for chronic illnesses.
subject: Articles
  topic: section
subject: immunoregulation
  topic: keywords
subject: macrophages
  topic: keywords
subject: chronic
  topic: keywords
creator: M Vamshi Krishna
creator: A. Purnima Devi
creator: B Sandhya Rani
creator: I. Triveni
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-01-02
publication date: 2024-01-02
starting page: 1
ending page: 33

Effects of Phosphate Fertilizers on Soybean Performance
type: item
description: For the development and production of soybeans (Glycine max L.), phosphorus (P) is an essential macronutrient. The effects of different phosphorus fertilizer rates on soybean growth, development, and yield characteristics are examined in this research. Plant height, leaf area index, pod number, seed output, and phosphorus use efficiency (PUE) were all assessed in field studies. The results show that at ideal phosphorus application rates, growth and yield metrics were improved, but at excessive or inadequate rates, performance was hampered. The research offers helpful suggestions for sustainable phosphorus management and emphasizes the significance of phosphorus optimization in raising soybean output.
subject: Articles
  topic: section
subject: phosphorus
  topic: keywords
subject: fertilizer
  topic: keywords
subject: macronutrient
  topic: keywords
creator: D.Dhachinamoorthi
creator: K Balaram Kumar
creator: L. Ramachandra Reddy
creator: M.Rajan
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2023-03-02
publication date: 2023-03-02
starting page: 47
ending page: 50

Economic Evaluation of FDA-Approved Small Molecule Protein Kinase Inhibitors in Oncology and Non-Oncology Indications in the United States
type: item
description: Protein kinases are the focus of several drug discovery initiatives across the globe because genetic changes such as mutations, overexpression, translocations, and dysregulation of these enzymes contribute to the pathophysiology of numerous diseases. Of the 80 small molecule protein kinase inhibitors that the FDA has authorized, 77 are oral bioavailable medications. According to the information, 69 of these medications are authorized to treat neoplasms, including solid tumors like lung and breast cancer as well as non-solid tumors like leukemia. The remaining 11 medications also target non-neoplastic conditions such ulcerative colitis, rheumatoid arthritis, and psoriasis. The FDA label was used to calculate the dose and quantity of pills needed daily, and the cost of the medications was retrieved from www.pharmacychecker.com. Any government or private insurance coverage, which would pay the whole cost or, more likely, a portion of the advertised price, is not included in this technique. Treatment of neoplastic illnesses averaged $17,900 a month, with futibatinib (used to treat cholangiocarcinomas with FGFR2 fusions) costing $44,000 and binimetinib (melanoma) costing at least $5100. With a high of $17,000 for belumosudil (graft vs. host disease) and a minimum of $200 for netarsudil eye drops (glaucoma), the average monthly cost for treating non-neoplastic disorders was $6800. The incidence of the targeted condition is negatively correlated with the cost of the medications. Since there are less than 200,000 possible patients in the US, several of these medications are or were categorized as orphan pharmaceuticals.
subject: Articles
  topic: section
subject: initiatives
  topic: keywords
subject: orphan pharmaceuticals.
  topic: keywords
subject: medications
  topic: keywords
creator: K Ravindranadh
creator: L. Ramachandra Reddy
creator: G.Pitchaiah
creator: K.Naga Hari Krishna
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2023-02-02
publication date: 2023-02-02
starting page: 15
ending page: 46

Homeopathy's effects on HIV-positive individuals
type: item
description: HIV+ people, those with early-stage AIDS, and those with less severe cases of AIDS may all benefit from homeopathic medications. However, most homeopaths don't see significant improvements in the treatment of patients with advanced stages of AIDS. However, it should be noted that there are exceptions to this general pattern, and some homeopaths find that some patients with advanced stages of AIDS see a dramatic improvement in their quality of life. Given the seriousness of certain AIDS patients' conditions, several homeopaths investigate novel homeopathic treatments and unconventional approaches to homeopathy. [1]
subject: Articles
  topic: section
subject: HIV
  topic: keywords
subject: Homeopathic
  topic: keywords
subject: Patient
  topic: keywords
subject: Homeopaths
  topic: keywords
creator: Dr Vipul Avinash Shilahar
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-02-28
publication date: 2025-02-28
starting page: 42
ending page: 47

A review of the phytochemical studies of Momordica charantia
type: item
description: Traditional medicine makes use of Momordica charantia for a number of therapeutic purposes. Standard analytical techniques were used to examine the bitter gourd's phytochemical makeup. Additionally identified as either present or missing were phytochemicals such as tannin, flavonoids, phenolic compounds, alkaloids, saponins, steroids, cardiac glycosides, phlobatannins, and anthraquinones. The percentages of tannin, flavonoids, phenolic compounds, alkaloids, and saponins were shown in the proximate composition.
subject: Articles
  topic: section
subject: Momordica charantia
  topic: keywords
subject: medicinal plant
  topic: keywords
subject: homoeopathy
  topic: keywords
subject: Phyto chemical studies
  topic: keywords
creator: Dr Vipul Avinash Shilahar
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-02-28
publication date: 2025-02-28
starting page: 37
ending page: 41

A STUDY TO ASSESS THE EFFECTIVENESS OF PLANNED TEACHING PROGRAMME REGARDING CHILDHOOD OBESITY AMONG THE MOTHERS OF SCHOOL GOING CHILDREN IN URBAN AREA
type: item
description: Introduction: Obesity is a growing problem that is expected to persist and to have long-term negative effects on the health of individuals and populations unless action is made to reverse the trend. Obesity is a problem that is becoming increasingly severe. It has been hypothesized that the development of obesity is caused by a variety of different environmental factors. Material & Methods: It was a pre-experimental design with one group that included a pretest and a posttest. The current research was carried out on mothers of children who were between the ages of 8 and 10 years old and who lived in various parts of the Coimbatore district. In accordance with the purposive sample method, sixty mothers were chosen for collection. Result: In the post-test, the major of the subjects, 35 (88%) had a score that indicated moderate knowledge, whereas in the pre-test, none of the samples, 11 (18%), had a score that indicated moderate knowledge whatsoever. Given that the mean score on the post-test knowledge test (12) was higher than the mean score on the pre-test knowledge test (7.8), it may be inferred that the PTP was successful in enhancing the knowledge regarding mother's obesity. At the 0.05 level of significance, it was discovered that there was a highly significant difference in the mean scores of mothers' knowledge of obesity based on their pre-test and post-test scores. Conclusion: After analyzing the results of the study, the researchers came to the conclusion that the planned training program about obesity was extremely effective (t = 9.6) in terms of increasing mothers' knowledge.
subject: Articles
  topic: section
subject: Effectiveness
  topic: keywords
subject: planned teaching programme
  topic: keywords
subject: obesity
  topic: keywords
subject: mothers
  topic: keywords
subject: school children
  topic: keywords
creator: Mrs. Pushpa. P
creator: Prof.Dr. Ruby Anitha. D
creator: Mrs. Rincy Kavitha.D
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-05
publication date: 2025-11-05
starting page: 10
ending page: 19

Stress tolerance and adaptation as criteria for evaluating top rice genotypes in both typical and water-limited settings
type: item
description: The results showed that compared to irrigated circumstances, crop height, effective panicles per m², and grain production were all 22% lower under moisture-restricted conditions. Among the strains tested, IR17L1387, IR16L1713, and IR16L1801 had the best stress tolerance index (STI), suggesting that they might thrive in environments with limited water availability. Sukhadhan 3 genotype showed the highest degree of stability in both settings, according to GGE biplot analyses (Which-Won-Where and Mean vs. Stability). Furthermore, under conditions where moisture was scarce, the winning genotype was IR16L1713, while in conditions where water was abundant, the winning genotype was IR17L1387.
subject: Articles
  topic: section
subject: biplot
  topic: keywords
subject: stability
  topic: keywords
subject: stress tolerance
  topic: keywords
subject: irrigated
  topic: keywords
subject: rice
  topic: keywords
creator: Poudel
creator: Sushil Subedi
creator: Bimasu
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-07-30
publication date: 2025-07-30
starting page: 29
ending page: 36

Animal items containing heavy metals, such as milk and red meat
type: item
description: The demand for heavy metals has lately skyrocketed, and it's only going to keep going up in the future, thanks to factors including a growing global population, higher birth rates, and diverse resource demands. Our food supplies, particularly milk and meat from animals, are exposed by this problem. Multiple studies and publications have shown that these food sources are often polluted, and that people may readily bring this contamination into their diets by consuming these goods. The purpose of this paper is to provide a concise summary of the topic, then to analyze it using scientific reports.
subject: Articles
  topic: section
subject: heavy metals
  topic: keywords
subject: livestock products
  topic: keywords
subject: milk
  topic: keywords
subject: red meat, pollution
  topic: keywords
creator: Aurelie Pradeau
creator: Carsten Schradin
creator: Michael D
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-01-21
publication date: 2025-01-21
starting page: 32
ending page: 35

Rice crop enhancement using the CRISPR/Cas9 genome editing technology
type: item
description: A key component of food security is the ability of crops to withstand both biotic and abiotic stresses, as well as their own production and quality. We need to develop more rapid methods to produce high- yielding, climate-resilient rice varieties with excellent grain quality if we are to meet the food needs of almost 10 billion people by the year 2050. The rice crop's stress tolerance qualities, yield, and quality have all been enhanced via the use of different techniques. Of these, traditional breeding techniques have recently increased agricultural yields by a small margin. An essential breeding strategy that has helped isolate new high-yielding genotypes of rice and produced several new varieties is mutation breeding. In traditional mutant breeding, forward and reverse genetic techniques have been used to find genomic variations, which have then been characterized in order to use them as functional markers to create new, better kinds. Due to the random nature of gene modifications and the use of physical and chemical mutagens in mutagenesis, standard breeding approaches like random mutagenesis make it very laborious to generate desired mutations in the desirable area of the crop genome.
subject: Articles
  topic: section
subject: CRISPR/Cas9
  topic: keywords
subject: crop improvement
  topic: keywords
subject: mutagenesis
  topic: keywords
subject: mutations
  topic: keywords
subject: genome editing
  topic: keywords
subject: rice
  topic: keywords
creator: Edward Paul Abbey
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-07-31
publication date: 2024-07-31
starting page: 44
ending page: 48

The ultrastructure, control, and function of plasmodesmata in the transport of assimilates across plant cells
type: item
description: Direct symplastic transport of chemicals, including photoassimilates, is made possible by tiny channels called plasmodesmata, which link neighboring plant cells. Their function in regulating the transfer of assimilates from source tissues to sink tissues and in intercellular communication is critical. The efficiency of sucrose and other carbohydrate transport is affected by the form, frequency, and permeability of plasmodesmata, which in turn affects plant growth and production. Under both normal and stress settings, plasmodesmata play an important role in nutrient partitioning, and this review delves into their ultrastructure and the molecular processes that control their regulation. Recent developments in imaging methods, molecular gating, and strategies for loading and unloading phloem with plasmodesmal function are highlighted. By delving into these channels, we may get valuable insights into how to enhance crop production by precisely manipulating assimilate transport processes.
subject: Articles
  topic: section
subject: Plasmodesmata
  topic: keywords
subject: symplastic transport
  topic: keywords
subject: phloem loading
  topic: keywords
subject: source–sink relationship
  topic: keywords
creator: John Donne
creator: Henry David Thoreau
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-06-30
publication date: 2024-06-30
starting page: 44
ending page: 48

SCREENING OF ALLELOPATHIC ACTIVITY OF CARDIOSPERMUM HALICACABUMLINN. (KAPALPHODI) ON TRITICUM AESTIVUM (WHEAT) AND VIGNA RADIATA (MUG)
type: item
description: An organism that generates one or more biochemicals that affect the development, survival, and reproduction of other species is said to exhibit allelopathy. These biochemicals, also known as allelochemicals, can affect the target organism in both positive and negative ways. Allelopathic effect of Cardiospermum halicacabumLinn.(Kapalphodi) was studied in aqueous extract at various concentrations on germination percentage and growth of plumule and radicle (In vitro and In vivo) on Triticum aestivum (Wheat) and Vigna radiata (Mug). Germination percentage, plumule growth and radicle growth of Triticumaestivum (Wheat) and Vigna radiata (Mug) were significantly affected by flavonoids present in aqueous extract of Cardiospermum halicacabumLinn.(Kapalphodi)at higher concentrations with respect to control; In vitro and In vivo. Flavonoids in aqueous extract of Cardiospermum halicacabumLinn.(Kapalphodi)were confirmed by using IR spectroscopy.
subject: Articles
  topic: section
subject: Allelochemicals
  topic: keywords
subject: Aqueous extract
  topic: keywords
subject: Cardiospermum halicacabumLinn.(Kapalphodi)
  topic: keywords
subject: Triticum aestivum (Wheat)
  topic: keywords
subject: Vigna radiata (Mug)
  topic: keywords
subject: IR spectroscopy
  topic: keywords
creator: Rodage T. S
creator: Shirame S. P
creator: Atar S. S
creator: M. R. Pethakar
rights: Copyright (c) 2025 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-08
publication date: 2025-10-08
starting page: 1
ending page: 9

A case report on the 50th millesimal potency of homeopathic treatment for chronic cholelithiasis
type: item
description: Gallstone disease, also known as cholelithiasis, is a relatively prevalent issue globally. Females are more likely than men to have it. Cholecystectomy has its own dangers, limits, and post-operative problems, while being the gold standard therapy for symptomatic cholelithiasis. Here, cholelithiasis is well treated using an alternative medical system, particularly homeopathy. An overview of the case: A 32-year-old woman patient complained of regurgitation, sour eructations, and dull discomfort in the right hypochondrium. According to the ultrasonography (USG) report, there are many stones in the gallbladder that range in size from 3 mm to 11 mm. She was recommended to have a cholecystectomy, but she refused to have any surgery done. Lycopodium was administered in fifty millesimal potencies after a thorough case analysis, totality formation, and repertorization. After three months of therapy, USG tests showed that there were no stones, and her symptoms quickly subsided. Homeopathic medicine In this instance, lycopodium, which was chosen based on the severity of the symptoms, proved to be beneficial.
subject: Articles
  topic: section
subject: Lycopodium
  topic: keywords
subject: cholecystitis
  topic: keywords
subject: Cholelithiasis
  topic: keywords
subject: gallbladder
  topic: keywords
subject: homeopathy
  topic: keywords
creator: Musheer Shabbir Ahmaed Jamadar
rights: Copyright (c) 2024 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-09-09
publication date: 2024-09-09
starting page: 37
ending page: 43

To determine the efficacy of homoeopathic remedies for chronic rhinosinusitis, researchers conducted a randomized, placebo-controlled, parallel-arm experiment
type: item
description: Background: One major health issue that affects people's health-related quality of life is chronic rhinosinusitis (CRS). This research aims to evaluate the effectiveness of individualized homoeopathy (IH) on LM potency in chronic renal failure (CRF). Methods: From July 2012 to December 2013, four institutions conducted a randomized, double-blind, placebo-controlled study on CRS patients. Sixty people met the criteria and were randomly assigned to either receive IH in LM-potencies or a comparable placebo. Area under the curve (AUC) for total symptoms score (TSS) and sinus nasal outcome test 22 over a 3-month period was the primary outcome measure. For the analyses, the intention-to-treat method was used. The results showed that the homoeopathy group had a lower TSS AUC over 3 months compared to the placebo group, but this difference was not statistically significant (IH: 1303.1 ± 612.2; P = 1380.1 ± 811.8; 95% CI: −336.9, 182.9; P = 0.56). In favor of homoeopathy, there was a statistically significant difference between the absolute change in TSS from baseline at days 60 and 75, with a mean difference of 4 (95% CI: 0.3-7.7, P = 0.03) and 3.8 (95% CI: 0.1-7.5, P = 0.04), respectively. At day 75, the investigator and patient both noted significant improvements; at day 60, the difference was 0.5 (95% CI: 0.27-0.84, P = 0.0001), and at day 75, the difference was 0.6 (95% CI: 0.27-0.86, P = 0.0001). In the homoeopathy group, there was a noticeable upward trend in the rhinoscopy score (mean difference: 0.9, 95% CI: −0.00-1.8, p=0.05). Scores on computed tomography scans of the paranasal sinuses were similar between groups. The results of this study suggest that individuals with CRS may benefit from using homoeopathic treatments that are tailored to their specific needs, and the research should continue in this direction.
subject: Articles
  topic: section
subject: Chronic rhinosinusitis
  topic: keywords
subject: Individualised Homoeopathy
  topic: keywords
subject: Randomised controlled trial
  topic: keywords
subject: Sino-nasal outcome test-22
  topic: keywords
subject: Total symptoms score
  topic: keywords
creator: Musheer Shabbir Ahmaed Jamadar
rights: Copyright (c) 2024 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-08-30
publication date: 2024-08-30
starting page: 25
ending page: 36

A report on a case of prurigo nodularis that responded to homeopathy
type: item
description: A benign, long-lasting neurodermatitis is called Prurigo nodularis (PN). We don't know the precise reason. Even with therapy, the nodules in the majority of PN instances do not completely disappear. An overview of the case: Here, an 18-year-old woman with a history of a 1-year-old eczematous lesion is diagnosed with PN. Natrium muriaticum, a homoeopathic remedy, was recommended based on the whole of the patient's symptoms. Over the course of four months, the patient's signs and symptoms progressively improved steadily and went into remission. Over the next year, there was no recurrence. It is clear from this case study that homoeopathy may be used as a therapeutic alternative to treat PN patients.
subject: Articles
  topic: section
subject: case study
  topic: keywords
subject: Prurigo nodularis
  topic: keywords
subject: Natrium muriaticum
  topic: keywords
subject: homeopathy
  topic: keywords
creator: JYOTI SANJAY UTAGE
rights: Copyright (c) 2024 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-08-23
publication date: 2024-08-23
starting page: 19
ending page: 24

A web-based cross-sectional research on the knowledge, awareness, attitude, and behavior of Indian homoeopathic physicians about pharmacovigilance in homoeopathy
type: item
description: Background: Pharmacovigilance refers to the study and practice of identifying, evaluating, comprehending, and avoiding medication-related issues, including adverse effects. If we want accurate data on the safety of Ayurvedic, Yoga, Naturopathic, Unani, Siddha, and Homoeopathic medications, we need to study this topic. The purpose of this research was to examine how homoeopathic doctors felt about the Pv programme in terms of their knowledge, awareness, attitude, and practice (KAAP). Approach: Over the course of two months, 274 homoeopathic practitioners in India participated in an online cross-sectional survey. After consulting with three industry professionals, the research team created a questionnaire and shared it across various social media accounts using a randomly generated link. Through an online portal, the data collecting format was communicated to the interested participants who gave their permission to the research. Four domains were used to get the data: KAAP. The data was analyzed using descriptive statistics, and the subgroup analysis was done using independent t-tests. Findings: A total of 265 homoeopathic practitioners (96.7% response rate) agreed to fill out the questionnaire after being contacted with the request. When asked about their familiarity with the software, the majority of research participants scored poorly. Postgraduates and those with previous Pv training showed statistically significant differences. Participants had a generally positive outlook on the program's acceptability, although they were less likely to notice and report adverse drug reactions (ADRs) in homoeopathy due to a lack of knowledge. Despite homoeopathic practitioners' positive attitudes toward the Pv programme, there is still a lack of adequate hands-on training for identifying and reporting adverse drug reactions in homoeopathy.
subject: Articles
  topic: section
subject: Adverse drug event
  topic: keywords
subject: Adverse drug reaction
  topic: keywords
subject: Homoeopathy
  topic: keywords
subject: Knowledge
  topic: keywords
subject: awareness
  topic: keywords
subject: attitude and practice
  topic: keywords
subject: Pharmacovigilance
  topic: keywords
creator: JYOTI SANJAY UTAGE
rights: Copyright (c) 2024 https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2024-07-31
publication date: 2024-07-31
starting page: 10
ending page: 18