Melastoma decemfidum Flower, Leaf, and Stem Extract Exhibits Antibacterial Activity

Abstract

Amisulpride is an atypical antipsychotic drug that inhibits the dopamine (D2 /D3) receptor. The oral
bioavailability of amisulpride was less than 48% as a result of inadequate aqueous solubility and first-pass
metabolism. Amisulpride is classified as a BCS Class II substance.This study aims to create a controlled release
formulation that maintains plasma concentration by administering a reduced dose of the drug. This formulation
may improve patient compliance, therapeutic efficacy, bioavailability, and side effects by altering the delivery
pattern through the slow release of the drug from microparticles. The objective of the current research was to
utilize emulsification crosslinking and Ionotropic Gelation techniques to develop and optimize Amisulpride-
loaded microparticles with Chitosan natural polymer. A total of 8 formulations were developed. Formulations F1
to F4 were prepared using the emulsification crosslinking method, which involves the use of chitosan as a natural
polymer for controlled release and varying concentrations of TPP (as a crosslinking agent). Formulations F5 to
F8 were prepared using the Ionotropic Gelation technique, which involves the same composition. The
characterization of all formulations includes dimension analysis, flow properties, % Drug Content, %
Encapsulation Efficiency, Wall thickness, SEM Analysis, IR Sprectroscopy, and evaluation for invitro drug
release studies. The results of this study indicated that the microparticles formulated using the Ionotropic gelation
method and the Emulsification Crosslinking method exhibited substantial variations in their permeability
coefficient values and release rates. It was determined that the Emulsification Crosslinking method was more
appropriate for sustained release due to its improved bioavailability and delayed release of Amisulpride.