Synthesis and Evaluation of Some Substituted Indole Derivatives for Cardiovascular Activity

Abstract

This research delves into a class of indoles that have thiazolidinone and oxadiazole side chains attached to their
3-position. Evaluation of cardiovascular activity was conducted on the synthesized Indole derivatives 4 (a-e) and
5 (a-e). This compound is 3-[5'-(3"-indolomethylene)-1',3',4'-oxadiazol-2'-yl]At 2.5 mg/Kg, the most active
ingredient in the current investigation, 2-(p-methoxy phenyl)-4-thiazolidinone 5b, exhibited different degrees of
cardiovascular activity. Using infrared, 1H nuclear magnetic resonance, mass spectrometry, and elemental
analysis, the structures of these substances were revealed.