Macrophage-Based Therapeutic Strategies: Phenotypic Transition Control and Drug Delivery System Development

Abstract

Macrophages, being highly phenotypic changeable immune cells, have distinct functions in different clinical
situations. Modifying and managing macrophage morphologies is seen as a unique possible therapeutic
intervention. In the meanwhile, several transmembrane proteins that attach on the macrophage membrane's
surface remain comparatively preserved, maintaining its functional characteristics including tumor targeting and
inflammatory chemotaxis. As a result, a number of medication delivery mechanisms associated with certain
macrophage membrane proteins are often used to treat chronic inflammatory disorders. The regulation of
macrophage phenotypes and their polarization processes, the design and implementation of site-specific targeted
drug delivery systems in vivo based on macrophages and their derived membrane receptors, and a summary of
macrophage-based strategies for chronic diseases are all covered in this review. It seeks to advance knowledge
of macrophages' role in immunoregulation and suggests tailored therapy strategies based on macrophages for
chronic illnesses.