Assessment of Anti-Obesity Activity of Tramarindus Leaves on Butter Induced Hyperlipidemmia in Mice

Abstract

Obesity is one of the world’s leading problems, which is major cause of Cardiovascular Diseases. During covid- 19
pandemic many young children and all age group people are getting challenged by obesity due stagnant life style. To treat
such life threatening disorder natural remedies acquire prior position, Plant produce a good deal of secondary metabolites
which have a benifited mankind in various ways, including treatment of disesses The present research work was focused
on developing a natural remedy using Tamarindus indica,, an ancient plant with number of proven activities in
Treditional medicine. In the literature survey, it was found that flavanoids, sterols, tannins and alkaloids shown promising
effects to tackle obesity by various mechanisms, Tramarindus indica has shown the presence of sapponins, flavanoids,
glycosides, amino acids, alkaloids. With the above evidence, this plant has been selected for screening of its antiobesity
activity against high fat diat induced obesity in mice. Studies were conducted using aqueous extract of Tamarindus indica
leaves (AETI) on high fat diet (butter) induced model of hyperlipidemia in mice. During 21 days time period AETI low
and high doses were induced to respective animal groups along with butter where Atorvastatin has been taken as standard
drug. Butter enhanced the Cholesterol and triglyceride, LDL levels. At the end of 21 days blood samples were collected
from the animal through retroperitoneal route. Biochemical parameters of AETI have been revealed its antiobesity activity.