Phytochemical Analysis and Wound Healing Activity of Ugandan Zanthoxylum Species

Abstract

The purpose of this research was to assess the effectiveness and potential mechanism of Zanthoxylum species stem
bark utilized by communities and herbalists in South Western Uganda for wound healing.
Methodology: a randomized controlled trial.
Location and Time Frame: Mbarara University of Science and Technology, Faculty of Medicine, Departments of
Pharmacy, Pharmacology, and Pharmaceutical Sciences. Between August 2016 and February 2017, the research
was conducted.
Animals were split into four groups: Group I (Zanthoxylum spp (Zanthoxylum species) water extract) (n=9), Group
2 (control herbal drug) (n=6), Group 3 (distilled water) (n=9), and Group 4 (neomcycine antibiotic) (n=3). For 15
days, twice-daily treatments were performed. Areas of wounds were measured on days 1, 6, and 15 for all animals
in groups 1, 2, and 3.
On days 6 and 15, the percentage of the wound area that had healed was measured and compared statistically.
Histology evaluation of wound tissues required the humane slaughter of rats in gr oup 4 on day 7 and three rats
randomly selected by a blinded laboratory worker from groups 1 and 3. The water extract of Zanthoxylum spp. was
analyzed physicochemically, and the impact of each solvent on extract potency was calculated.