Assessing the potential toxicity of Assessing the potential toxicity of Assessing the potential toxicity

Abstract

Using an animal model, this study aims to demonstrate that Sargassum plagiophyllum extract is safe for human
consumption. Methods: An autoclave set at 121°C for 20 minutes was used to extract water from Sargassum
plagiophyllum, which is known as SPE. For 21 days, four groups of adult male mice were gavaged with the SPE.
A range of SPE doses—100, 500, 1000, and 2000 mg/kg—were administered to the treatment groups. Mice
served as controls were given pure water. Individuals' dietary consumption, as well as their weight, were
documented. Blood, biochemical, and histological indicators were used to evaluate the toxicity of SPE. Findings:
Not even at 2000 mg/kg did 21 days of SPE ingestion affect body mass, feed intake, or water intake. Additionally,
there was no change in hemodynamic parameters. The results of the biochemical examination of the blood and
serum showed that all of the treatment groups, in comparison to the control group, had normal levels of
creatinine, alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP). Organs
such as the liver, kidneys, colon, and others were found to be in good health across all therapy groups, according
to histological investigations. In conclusion, our mouse model findings broaden the potential medicinal
application of Sargassum plagiophyllum extract by providing fundamental scientific proof that it is safe to
consume, even at large dosages. Sargassum plagiophyllum, brown algae, animal testing, histopathology, and
safety