Shifting Focus from Fundamentals to Systems Pharmacodynamic Models

Abstract

A number of PK/PD models have been established, building on various
classical pharmacology foundations; these models are based on the principles of
pharmacological action and the primary physiological processes that limit or turnover the
drug's effectiveness. You can design better PK/PD or small system models by adding
complexity to many fundamental models; tolerance is only one of many such additions.
We demonstrate all of these concepts in our corticosteroid models, along with features
of the horizontal and vertical integration of molecular to whole-body processes. The
potential advantages and disadvantages of moving PK/PD towards systems models are
outlined here. The paper "J Pharm Sci 102:2930-2940" was published in 2013 and was
written by Wiley Periodicals, Inc. and the American Pharmacists Association. Words like
"pharmacodynamics," "systems pharmacol-ogy," "mathematical models," "dosage
response," and "indirect response models" are utilized.