A RESEARCH PROPOSAL: COMBINATORIAL NOVEL DRUG DELIVERY APPROACH OF THE MANAGEMENT OF ACNE-VULGARIS

Abstract

Chronic skin illness known as acne vulgaris is mostly brought on by obstructions in the sebaceous glands or inflammation in those
glands, which are collectively referred to as pilosebaceous units. It mostly affects the face, back, and upper chest, which are the regions
with the greatest concentration of sebaceous follicles. This illness may strike anyone of any age, although it mostly affects adolescents.
These may manifest as non-inflammatory closed comedones (whiteheads), open comedones (blackheads), inflammatory pustules, papules, cysts, and nodules, or a combination of symptoms. It is most usual for practically everyone to have acne at some time in their life. There are 20–25 percent odds that acne may worsen to the point where it leaves permanent scars. Psychological issues including sadness, social isolation, poor self-esteem, and low self- confidence are brought on by these obstacles. The purpose of acne treatment is to avoid serious, long-term consequences. The innovative medication delivery methods for the treatment of acne are the main topic of this review. It also covers the limits of the traditional medicines that are now on the market, as well as other approaches to get around them.