DESIGN AND OPTIMIZATION OF HYDRODYNAMICALLY BALANCED GASTRORETENTIVE DRUG DELIVERY OF INDAPAMIDE USING NATURAL AND SYNTHETIC POLYMERS

Abstract

The objective of this research was to prepare a Gastroretentive drug delivery system of Indapamide. Quick GI
transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to
decreased efficacy of the administered dose and thus less patient compliance. Indapamide is a thiazide-like
diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as
decompensated cardiac failure. The main objective of this work was to investigate the possibility of improving the
solubility and dissolution rate of Indapamide by preparing gastroretentive Floating Tablets using Natural and
synthetic polymers By Using Wet Grannulation Technique. Then the formulation was developed by using different
concentrations of polymers of gum cyamopsis, Polyox Coagulant and Polyox 303 as polymeric substances. The
formulation blend was subjected to various preformualation studies, flow properties and all the formulations were
found to be good indicating that the powder blend has good flow properties. Among all the formulations the
formulations Polyox 303 as polymer were retarded the drug release up to desired time period i.e., 12 hours in the
concentration of 30 mg. whereas in low concentrations the polymer was unable to produce the desired action. (F8
Formulation, 96.98 ± 1.08% Drug release). The optimized formulation dissolution data was subjected to release
kinetics; from the release kinetics data it was evident that the formulation followed higuchi release kinetics.