Comparative Anti-inflammatory Activity of NSAIDs and Herbal Extracts in Carrageenan-Induced Paw Edema

Abstract

To assess the anti-inflammatory properties of fresh Zingiber officinale rhizome aqueous and methanolic extracts: 1. To use the Carrageenan-induced paw edema technique to test the anti-inflammatory activity of all extracts in two dosages and the standard medication in wistar rats. 2. To contrast the two extracts' anti-inflammatory properties with those of a prescription medication. The research was carried out with consent from the animal ethics committee. There were six groups of animals. While test groups received aspirin (150 mg/kg), aqueous extract of fresh Z. officinale rhizome (100 and 200 mg/kg), and methanolic extract of fresh Z. officinale rhizome (100 and 200 mg/kg), the control group received 0.2 ml NS IP. Ginger's anti-inflammatory properties were examined using an acute model of inflammation that included rat paw edema caused by carrageenan. Aqueous and methanolic extracts of fresh rhizome had considerable anti-inflammatory effect (p < 0.05) in the acute model of inflammation when compared to control, and at all time intervals, their activity was equivalent to that of aspirin. Gingiber officinale extracts, both aqueous and methanolic, have strong anti-inflammatory effects.