Synthesis, Docking, Antimicrobial Activity, and Cytotoxic Potential of Two-Arylquinazolinones

Abstract

Purpose With the emergence of the AIDS pandemic, antifungal medicines have been increasingly used in human
medicine. New antimicrobial compounds have been discovered as a result of the widespread usage of antifungal
medications and the development of resistance to these treatments among fungal diseases. The relatively high risk
of toxicity and the establishment of drug resistance have reduced the therapeutic utility of the increasing list of
azole medicines. The development of drug resistance in tumor cells and the toxicity of chemotherapy on vital
organs are common limitations of the treatment. Therefore, research has focused on creating novel antifung al and
cytotoxic medicines with improved efficacy and reduced toxicity.
Methodology: a series of 2-arylquinazolinones with antifungal and cytotoxic properties were prepared.
Shiraz University of Medical Sciences, Shiraz, Iran, Department of Medicinal Chemistry, Department of Medical
Mycology, and Institute for Cancer Research, October 2016 - September 2017.