Cardioprotective Effects of Ginsenoside Rg1 in Patients Suffering from Acute Myocardial Infarction

Abstract

Ginsenoside Rg1 (Rg1), the active component of Panaxnotoginseng, has a cardioprotective effect. However, Rg1's
effectiveness against acute myocardial infarction (MI) remains unclear. The purpose of this research was to learn how
Rg1 provides cardio-protection. The aim of this study was to produce myocardial infarction in wistar rats by occluding
their left anterior descending coronary artery. Immunohistochemical staining was used to assess neutrophil and
macrophage infiltration, and the terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL)
assay was used to detect apoptosis. 2,3,5-triphenyltetrazolium chloride (TTC) staining was used to detect infarct size.
Principal Results: Superoxide dismutase (SOD) activity was considerably increased and myocardial infarct size was
decreased after treatment with Extract Rg1 (P 0.01) or Ferment Rg1 (P 0.01). Then, HE and PTAH stain showed that
Extract Rg1 and Ferment Rg1 protected heart structure, particularly sarcomere integrity. Extract Rg1 (P 0.001) and
Ferment Rg1 (P 0.001) both decreased the amount of apoptotic cells and blocked neutrophil infiltration into the cardiac
infarct site.