Preparation and In-vitro Evaluation of Microballoon Drug Delivery System of Telmisartan

Abstract

In this study, researchers attempted to create Telmisartan microballoons using the emulsion solvent diffusion
technique. The goal was to use polymers like HPMC and Eudragit RS 100 to prolong the drug's release in the
upper gastrointestinal tract (GIT) for approximately 12 hours. This could lead to better absorption and
bioavailability. The optical micrometer was used to measure the particle size, which ranged from 189.5± 2.63 to
124.33± 2.14 on average. When compared to other formulations, Formulation F7, which had a combination of
HPMC and Eudragit polymer, exhibited the highest floating ability at 91.26%. Scanning electron microscopy
(SEM) revealed that the microballoons had a smooth outside and an inside hollow region. F7 was the best
formulation since it achieved a 98.32% medication release rate in 12 hours while maintaining an optimum
buoyancy.